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KMID : 0383820160790030153
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Tuberculosis and Respiratory Diseases
2016 Volume.79 No. 3 p.153 ~ p.157
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Association of Serum Vitamin D Levels with Bacterial Load in Pulmonary Tuberculosis Patients
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B. Yuvaraj
M. G. Sridhar
S. Vinod Kumar
T. Kadhiravan
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Abstract
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Background : Vitamin D is known to have diverse effects on various systems in the body. There is evidence to suggest that a link exists between the serum vitamin D status and tuberculosis. The present study was designed to assess the alterations in serum 25-hydroxyvitamin D levels in newly diagnosed sputum acid fast bacilli (AFB) positive pulmonary tuberculosis patients and to study the association, if any, between serum vitamin D levels and different levels of sputum smear positivity.
Methods : Serum 25-hydroxyvitamin D levels were estimated in 65 sputum AFB positive pulmonary tuberculosis patients and 65 age and gender-matched healthy controls.
Results : The levels of serum 25 hydroxy-vitamin D in tuberculosis patients were not statistically different from the levels of serum 25 hydroxy-vitamin D in healthy controls. However, among patients with pulmonary tuberculosis, there was a significant negative correlation between the levels of serum 25 hydroxy-vitamin D and levels of sputum positivity.
Conclusion : Serum vitamin D levels negatively correlates with bacterial load in patients with active pulmonary tuberculosis.
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KEYWORD
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Vitamin D, Tuberculosis, Pulmonary
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